Charles Darwin used the term “dead reckoning” to describe the mysterious ability of most species to seamlessly navigate back home, even in the absence of external guiding cues. Finding our way home is indeed something most of us take for granted, but this facility is dramatically impaired in many people with Alzheimer’s disease, Parkinson’s disease, and epilepsy. Our research is motivated by a desire to understand how healthy neurons in the brain compute the way home and how these same neuronal computations fail in neurological and psychiatric disorders, with the ultimate goal of therapeutically repairing these neurons and computations. Read on for our papers, and please get in touch with Omar if you have questions about our research, want to support our work, or if you’re interested in joining or collaborating with the lab.

New Manuscripts from the Lab:

Psychedelics Decrease Excitability & Working Memory in Prefrontal Cortex

Ekins TG, Brooks I, Kailasa S, Rybicki-Kler C, Jedrasiak-Cape I, Donoho E, Mashour GA, Rech J, Ahmed OJ (2023). Cellular rules underlying psychedelic control of prefrontal pyramidal neurons.

[bioRxiv PREPRINT]

Left-Right Brain Communicate Better When Running Faster or in REM Sleep

Ghosh M, Yang FC, Rice SP, Hetrick V, Lorenzo A, Siu D, Brennan EW, John TT, Ahrens AM, Ahmed OJ (2022). Running speed and REM sleep control two distinct modes of rapid interhemispheric communication. Cell Reports 40:111028

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Parallel Processing in Superficial Retrosplenial Ctx

Brennan EW*, Jedrasiak-Cape I*, Kailasa S, Rice SP, Sudhakar SK, Ahmed OJ (2021). Thalamus and claustrum control parallel layer 1 circuits in retrosplenial cortex. eLife, 10:e62207

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Human Inhibitory Neurons Dynamically Control Seizures

Ahmed OJ, John TT, Sudhakar SK, Brennan EKW, Lorenzo Gonzalez A, et al. (2020). Two modes of inhibitory neuronal shutdown distinctly amplify seizures in humans. Submitted

MEDRXIV PREPRINT

Speed Distinctly Controls the Amplitude vs Shape of Theta

Ghosh M*, Shanahan BE*, Furtak SC, Mashour GA, Burwell RD, Ahmed OJ (2020). Instantaneous amplitude and shape of postrhinal theta oscillations differentially encode running speed. Behavioral Neuroscience 134:6 516–528

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Retrosplenial Neurons can Compute like a Stable Compass

Brennan EW*, Sudhakar SK*, Jedrasiak-Cape I, John T, & Ahmed OJ (2020). Hyperexcitable neurons enable precise and persistent information encoding in the superficial retrosplenial cortex. Cell Reports 30:1598–1612

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Overlapping Sleep-Addiction Neural Circuits

Ahrens AM, Ahmed OJ (2020). Neural circuits linking sleep and addiction: animal models to understand why select individuals are more vulnerable to substance use disorders after sleep deprivation. Neuroscience & Biobehavioral Reviews 108:435-444

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